Daniel Lo has been active in both the Taiwanese and Mandarin pop music scenes. In 1997, he received recognition at the Golden Bell Awards for his naturally warm and charismatic hosting style. In 2001, his album "Grateful Thanks" (感心感谢) won him the Best Male Singer in a Dialect category at the 12th Golden Melody Awards. He was also nominated for the same award again in 2004 and 2006. Some of his notable works include “Endless Night” (茫茫到深更), “A Man’s Sweat” (男人的汗), and “A Wordless Ending” (无言的结局), which are deeply loved by fans for his soulful voice and touching melodies.

In 2019, he ventured into YouTube with his self-run channel “Big Bull Compares Everything” (大牛比较揽), which garnered wide popularity and became a successful example of an artist transitioning into new media. In 2022, he hosted the 33rd Golden Melody Awards, achieving record-breaking viewership across online platforms. In 2024, he collaborated with Golden Melody-winning producer Adia on the Taiwanese single “Ba Rui” (巴蕊), which sparked a viral craze with its catchy rhythm and humorous lyrics, becoming a widely loved “divine hit”.In early 2025, he released a festive song “Fortune God Comes to My Home” (财神到我家), bringing joy to the Lunar New Year season and continuing to showcase his creative vitality and relevance in the evolving music scene.